Hi, I need help with essay on Scopolamine Reseacrh. Paper must be at least 2000 words. Please, no plagiarized work!
Effective dose of the drug is imperative, as overdose of scopolamine results in delirium, paralysis of eyes, delusions, stupor and in certain cases, may result in death of the individuals. Etymology of scopolamine highlights that the term scopolamine was coined after the plant Scopolia where as hyoscine is coined from the scientific nomenclature of henbane called Hyoscyamus niger. Scopolamine is a competitive antagonist at the M1 receptor (muscarinic acetylcholine receptor) and therefore it is known as anticholinergic or anti-muscarinic drug (White et al, 2007). History of Scopolamine Scopolamine was the foremost component in Asthmador, to contradict smoking it was made available in the market between the years 1950s and 1960s. The drug also enables the individual to overcome asthma and bronchitis. Between 1940 and 1960, scopolamine was used to induce labour in the twilight sleep. The drug aids in eliminating pain as scopolamine influences brain functions responsible for self-awareness and self-control resulting in psychosis (Dictionary Definition). Tracing the history of the drug, in 1940, crime fiction’s classic novel, “Farewell My Lovely”, mentioned scopolamine in a private sanatorium. Later, in the year 1957, the drug had to suffer a small degree of disrepute through the film “I Was a Teenage Werewolf”. Scopolamine was used in World War II action classic “The Guns of Navarone” (1961). and in “Where Eagles Dare” (1968), as a Schutzstaffel truth serum. Scopolamine gained popularity in media for its enormous actions, “That’ll Be The Day” (1974), TV series, episode 1. in Rober Ludlum’s Matarese Dynasty (1979). It was used in kidnappings in X files “Red Museum” (1990). Scopolamine was also used in “The Mars Records” (2000). While in the year 2007, episode of a TV show, “Airborne” mentioned an individual wearing scopolamine patch (Dictionary Definition). Epidemiology of Scopolamine Anticholinergic drug called scopolamine is responsible for causing serious illness or death if ingested. History of the drug scopolamine reveals that the drug has always been misused throughout the United States, which resulted in poisoning due to innocence, lack of awareness and poor understanding of the user. The incidents of Jimson weed poisoning was reported in Texas, NYC and California between June- November 1994 (Epidemiologic Notes and Reports Jimson Weed Poisoning Texas, New York, and California, 1994). Pharmacology of Scopolamine Scopolamine is an alkaloid obtained from Solanaceae family. Datura and Scopola carniolica are the chief members from which scopolamine is derived from these plants and act as antimuscarinic in a similar manner as atropine with more impact on central nervous system. Therefore, the drug plays an important role in anaesthesia, in urinary incontinence, as an antispasmodic, act as a mydriatic as well as cycloplegic agent. It is the drug of choice in motion sickness. The drug is used for the treatment of excessive salivation, sialorrhoea, colicky abdominal pain, diverticulitis, bradycardia as well as for irritable bowel syndrome (Drug Bank). Pharmacodynamics of Scopolamine The drug is a muscarinic antagonist. The structure of scopolamine is similar to the neurotransmitter acetylcholine. The drug act by blocking the muscarinic acetylcholine receptors (M1). The drug is classified as an anticholinergic drug. The drug stops nausea and vomiting which occur due to motion sickness.